DRUG-seq2、PHDs-seq、SMART-seq2等技术介绍及应用文章汇总
DRUG-seq2部分文章情况：
1、昕瑞再生开发技术并应用的文章：Li J, et al. Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems. Cell Rep. 2023
2、临床样本应用发表文章：Zuo W et al. The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China. Lancet Infect Dis. 2024
昕瑞再生Drug-seq2技术助力新冠研究论文在《柳叶刀》子刊 (IF=56.3) 发表
3、构建完类器官做药筛的文章：Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery. Cell Stem Cell. 2025
4、中药筛选应用文章：Quality and composition control of complex TCM preparations through a novel "Herbs-in vivo Compounds-Targets-Pathways" network methodology: The case of Lianhuaqingwen capsules. Pharmacol Res. 2025
5、DRUG-seq2少量细胞高通量3’转录组测序技术汇总性应用案例
从标志物到全景图谱：DRUG-seq颠覆传统报告基因的筛选模式
6、虚拟细胞文章应用
(1)药物损伤大模型：A large-scale human toxicogenomics resource for drug-induced liver injury prediction. Nat Commun 16, 9860 (2025).
Nat. Commun. | 大规模人类毒性基因组学资源助力药物性肝损伤的早期预测
(2)主动学习大模型：Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes
Science｜闭环主动学习框架：利用转录组学驱动表型药物发现新范式
另附DURG-seq2结果报告：昕瑞再生DRUG-seq2分析报告模板（202401）.pdf
其他技术文章情况：
PHDs-seq高通量靶向转录组测序技术：针对特定目标基因做药物筛选的方法
PHDs-seq: a large-scale phenotypic screening method for drug discovery through parallel multi-readout quantification
Cell Regen l 一种同时检测多基因表达的大规模表型筛选方法PHDs-seq
另附PHDs-seq结果报告：昕瑞再生PHDs-seq分析报告模板.pdf
SMART-seq2微量细胞RNA测序技术：专门解决超微量细胞测序难题方法
SMART-seq — 适配微量细胞/微组织/类器官/胚胎的全长转录组测序
另附SMART-seq2结果报告：昕瑞再生SMART-seq2分析报告模板.pdf
scifi-RNA-seq：类器官样本（混合细胞样本）+药物筛选，做到单细胞级别测序方法
scifi-RNA-seq：百万级单细胞解析开启类器官精准药筛与机制研究新篇章
